Phrase by 'Francis Crick'
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It now seems very likely that many of the 64 triplets, possibly most of them, may code one amino acid or another, and that in general several distinct triplets may code one amino acid.
Author: Francis Crick - English ScientistNow , Them , May , Acid
It now seems certain that the amino acid sequence of any protein is determined by the sequence of bases in some region of a particular nucleic acid molecule.
Author: Francis Crick - English ScientistSome , Now , Protein , Determined
It has yet to be shown by direct biochemical methods, as opposed to the indirect genetic evidence mentioned earlier, that the code is indeed a triplet code.
Author: Francis Crick - English ScientistEvidence , Genetic , Code , Indirect
If the code does indeed have some logical foundation then it is legitimate to consider all the evidence, both good and bad, in any attempt to deduce it.
Author: Francis Crick - English ScientistBad , Good , Foundation , Good And Bad
If poly A is added to poly U, to form a double or triple helix, the combination is inactive.
Author: Francis Crick - English ScientistForm , Double , Combination , Triple
The meaning of this observation is unclear, but it raises the unfortunate possibility of ambiguous triplets; that is, triplets which may code more than one amino acid. However one would certainly expect such triplets to be in a minority.
Author: Francis Crick - English ScientistMore , Meaning , Expect , Observation
The balance of evidence both from the cell-free system and from the study of mutation, suggests that this does not occur at random, and that triplets coding the same amino acid may well be rather similar.
Author: Francis Crick - English ScientistRandom , Well , Study , Balance
How is the base sequence, divided into codons? There is nothing in the backbone of the nucleic acid, which is perfectly regular, to show us how to group the bases into codons.
Author: Francis Crick - English ScientistNothing , How , Us , Group
For simplicity one can think of the + class as having one extra base at some point or other in the genetic message and the - class as having one too few.
Author: Francis Crick - English ScientistThink , Some , Class , Simplicity
Do codons overlap? In other words, as we read along the genetic message do we find a base which is a member of two or more codons? It now seems fairly certain that codons do not overlap.
Author: Francis Crick - English ScientistMore , Words , Two , Find
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