Phrase by 'Francis Crick'
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Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.
Author: Francis Crick - English ScientistView , Study , My Own , Data
It seems likely that most if not all the genetic information in any organism is carried by nucleic acid - usually by DNA, although certain small viruses use RNA as their genetic material.
Author: Francis Crick - English ScientistSmall , Information , Use , DNA
It is one of the more striking generalizations of biochemistry - which surprisingly is hardly ever mentioned in the biochemical textbooks - that the twenty amino acids and the four bases, are, with minor reservations, the same throughout Nature.
Author: Francis Crick - English ScientistMore , Nature , Same , Four
Moreover the incorporation requires the same components needed for protein synthesis, and is inhibited by the same inhibitors. Thus the system is most unlikely to be a complete artefact and is very probably closely related to genuine protein synthesis.
Author: Francis Crick - English ScientistSystem , Protein , Same , Genuine
If, for example, all the codons are triplets, then in addition to the correct reading of the message, there are two incorrect readings which we shall obtain if we do not start the grouping into sets of three at the right place.
Author: Francis Crick - English ScientistStart , Three , Reading , Place
We've discovered the secret of life.
Author: Francis Crick - English ScientistLife , Secret , Discovered , The Secret Of
We are sometimes asked what the result would be if we put four +'s in one gene. To answer this my colleagues have recently put together not merely four but six +'s.
Author: Francis Crick - English ScientistSometimes , Result , Together , Colleagues
Unfortunately it makes the unambiguous determination of triplets by these methods much more difficult than would be the case if there were only one triplet for each amino acid.
Author: Francis Crick - English ScientistMore , Only , Difficult , Determination
This seems highly likely, especially as it has been shown that in several systems mutations affecting the same amino acid are extremely near together on the genetic map.
Author: Francis Crick - English ScientistTogether , Same , Acid , Map
It would appear that the number of nonsense triplets is rather low, since we only occasionally come across them. However this conclusion is less secure than our other deductions about the general nature of the genetic code.
Author: Francis Crick - English ScientistOnly , Nature , Low , Nonsense
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